The EGR1/2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The EGR1/2 Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Description: NAB2 acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
Function: Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).
Subunit Structure: Homomultimers may associate with EGR1 bound to DNA.
Post-translational Modifications: Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.
Similarity: The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression. Belongs to the NAB family